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α-Methylmethcathinone

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α-Methylmethcathinone
Clinical data
Other namesα,N-Dimethylcathinone; β-Keto-N-methylphentermine; β-Keto-α,N-dimethylamphetamine; β-Keto-α,α,N-trimethylphenethylamine; α-Methylmethcathinone; α-Me-MC; βk-Mephentermine; RAD-081; RAD081
Drug classNorepinephrine–dopamine releasing agent
Identifiers
  • 2-methyl-2-(methylamino)-1-phenylpropan-1-one
CAS Number
PubChem CID
Chemical and physical data
FormulaC11H15NO
Molar mass177.247 g·mol−1
3D model (JSmol)
  • CC(C)(C(=O)C1=CC=CC=C1)NC
  • InChI=1S/C11H15NO/c1-11(2,12-3)10(13)9-7-5-4-6-8-9/h4-8,12H,1-3H3
  • Key:JLVGGPQTLAPRPH-UHFFFAOYSA-N

α-Methylmethcathinone (α-Me-MC), also known as βk-mephentermine or as RAD-081, is a norepinephrine–dopamine releasing agent (NDRA) of the amphetamine, cathinone, and phentermine families.[1][2][3] It is the α-methyl analogue of methcathinone and the β-keto analogue of mephentermine.[1][2][3] The drug's EC50Tooltip half-maximal effective concentration values for induction of monoamine release are 153 nM for norepinephrine, 590 nM for dopamine, and 12,860 nM for serotonin in rat brain synaptosomes.[1][2][3] α-Methylmethcathinone was first described in the scientific literature by 2019.[1][2][3]

See also

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References

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  1. ^ a b c d Davies RA, Baird TR, Nguyen VT, Ruiz B, Sakloth F, Eltit JM, et al. (June 2020). "Investigation of the Optical Isomers of Methcathinone, and Two Achiral Analogs, at Monoamine Transporters and in Intracranial Self-Stimulation Studies in Rats". ACS Chemical Neuroscience. 11 (12): 1762–1769. doi:10.1021/acschemneuro.9b00617. PMC 10019599. PMID 32356961.
  2. ^ a b c d Nguyen V (2019). Analyzing Interactions Between Methcathinone Analogs and the Human Monoamine Transporters. Theses and Dissertations (Master of Science thesis). Virginia Commonwealth University. doi:10.25772/T1DW-MG60 – via VCU Scholars Compass.
  3. ^ a b c d Davies RA (10 July 2019). Structure-Activity Relationship Studies of Synthetic Cathinones and Related Agents. Theses and Dissertations (Doctor of Philosophy thesis). Virginia Commonwealth University. doi:10.25772/TZSA-0396. Retrieved 24 November 2024 – via VCU Scholars Compass.
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