Difemetorex
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| Routes of administration | Oral |
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| Formula | C20H25NO |
| Molar mass | 295.426 g·mol−1 |
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Difemetorex (INN) or diphemethoxidine (USAN) is a [[central nervous system|Central Nervous System (CNS) stimulant drug introduced in France in 1966 by the pharmaceutical company, Ciba-Geigy, and briefly used as an appetite suppressant and or weight loss aid into the early 1970s, sold under the brand name Cleofil. A member of the piperidine chemical class, difemetorex was described as having such a disruptive and intolerable side effect of insomnia that patient drug compliance suffered and frequency of clinical use decreased, resulting in withdrawal from the market and cessation of production, availability, accessibility, and overall recognition among related substances. It is only known to have been marketed in France, and has remained virtually non-existent in the current era."isbn2-8290-0039-0">Brudon P (1983). Médicaments pour tous en l'an 2000?: les multinationales pharmaceutiques suisses face au tiers monde : l'exemple du Mexique. France: Editions d'En bas. p. 207. ISBN 2-8290-0039-0.</ref>[1][2][3][4][5]
Synthesis
[edit]Alkylation of desoxypipradrol with ethylene oxide gives difemetorex.[6]
See also
[edit]- Desoxypipradrol
- Diphenylprolinol
- SCH-5472
- Fenproporex
- Mefenorex
- Adrafinil
- Ananxyl
- Paroxetine
- Pitolisant
- Raloxifene
- Minoxidil
- N-Methyl-3-piperidyl benzilate (JB-336, BZ)]]
References
[edit]- ^ Isbell H, Chrusciel TL (1970). "Dependence liability of "non-narcotic" drugs". Bulletin of the World Health Organization. 43 Suppl (Suppl): 1–111. PMC 2427633. PMID 4949109.
- ^ Stepanek J, Zolliker VR (June 1971). "[Circulatory effects of the anorectic Diphemethoxidine compared with the effects of Amphetamine and Aminorex]". Archives Internationales de Pharmacodynamie et de Therapie. 191 (2): 376–99. PMID 5089225.
- ^ Stepanek J (September 1972). "[Alteration of the acid-base equilibrium by the anorectic diphemethoxidine in comparison with the effect of amphetamine and aminorex]". Archives Internationales de Pharmacodynamie et de Therapie. 199 (1): 122–38. PMID 5072180.
- ^ Hall JA, Morton I (1999). Concise dictionary of pharmacological agents: properties and synonyms. Kluwer Academic. ISBN 0-7514-0499-3.
- ^ "The use of common stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances" (PDF). Retrieved 2010-03-23.[dead link]
- ^ GB 861815, "New hydroxyalkyl-piperidines", issued 1961, assigned to CIBA Ltd