Jump to content

Brain-specific angiogenesis inhibitor 3

From Wikipedia, the free encyclopedia

ADGRB3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADGRB3, BAI3, adhesion G protein-coupled receptor B3
External IDsOMIM: 602684; MGI: 2441837; HomoloGene: 1289; GeneCards: ADGRB3; OMA:ADGRB3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001704

NM_175642

RefSeq (protein)

NP_001695

NP_783573

Location (UCSC)Chr 6: 68.64 – 69.39 MbChr 1: 25.11 – 25.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.[5][6]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[6] The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons.[7]

The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.[8] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135298Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033569Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenetics and Cell Genetics. 79 (1–2): 103–108. doi:10.1159/000134693. PMID 9533023.
  6. ^ a b "Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3".
  7. ^ Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, et al. (August 2013). "The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons". Molecular Psychiatry. 18 (8): 943–950. doi:10.1038/mp.2013.46. PMC 3730300. PMID 23628982.
  8. ^ Bolliger MF, Martinelli DC, Südhof TC (February 2011). "The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins". Proceedings of the National Academy of Sciences of the United States of America. 108 (6): 2534–2539. Bibcode:2011PNAS..108.2534B. doi:10.1073/pnas.1019577108. PMC 3038708. PMID 21262840.

Further reading

[edit]
[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.