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Alpha-1D adrenergic receptor

From Wikipedia, the free encyclopedia

ADRA1D
Identifiers
AliasesADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2, adrenoceptor alpha 1D
External IDsOMIM: 104219; MGI: 106673; HomoloGene: 551; GeneCards: ADRA1D; OMA:ADRA1D - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000678

NM_013460

RefSeq (protein)

NP_000669
NP_000669.1

NP_038488

Location (UCSC)Chr 20: 4.22 – 4.25 MbChr 2: 131.39 – 131.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The alpha-1D adrenergic receptor1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.[5]

Receptor

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There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

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This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.[5]

Ligands

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Many α1 receptor ligands are non-selective for receptor subtypes.

Antagonists

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171873Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027335Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ADRA1D adrenergic, alpha-1D-, receptor".
  6. ^ Buckner SA, Milicic I, Daza A, Lynch JJ, Kolasa T, Nakane M, et al. (December 2001). "A-315456: a selective alpha(1D)-adrenoceptor antagonist with minimal dopamine D(2) and 5-HT(1A) receptor affinity". European Journal of Pharmacology. 433 (1): 123–127. doi:10.1016/s0014-2999(01)01519-9. PMID 11755142.
  7. ^ Cleary L, Murad K, Bexis S, Docherty JR (October 2005). "The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist". Autonomic & Autacoid Pharmacology. 25 (4): 135–141. doi:10.1111/j.1474-8673.2005.00342.x. PMID 16176444.
  8. ^ Indra B, Matsunaga K, Hoshino O, Suzuki M, Ogasawara H, Muramatsu I, et al. (June 2002). "(+/-)-Domesticine, a novel and selective alpha1D-adrenoceptor antagonist in animal tissues and human alpha 1-adrenoceptors". European Journal of Pharmacology. 445 (1–2): 21–29. doi:10.1016/s0014-2999(02)01601-1. PMID 12065190.
  9. ^ a b Proudman RG, Pupo AS, Baker JG (August 2020). "The affinity and selectivity of α-adrenoceptor antagonists, antidepressants, and antipsychotics for the human α1A, α1B, and α1D-adrenoceptors". Pharmacology Research & Perspectives. 8 (4): e00602. doi:10.1002/prp2.602. PMC 7327383. PMID 32608144.

Further reading

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