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UGT2B17

From Wikipedia, the free encyclopedia
UGT2B17
Identifiers
AliasesUGT2B17, BMND12, UDPGT2B17, UDP glucuronosyltransferase family 2 member B17
External IDsOMIM: 601903; MGI: 1919023; HomoloGene: 68144; GeneCards: UGT2B17; OMA:UGT2B17 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001077

NM_152811

RefSeq (protein)

NP_001068

NP_690024

Location (UCSC)Chr 4: 68.54 – 68.58 MbChr 5: 87.06 – 87.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

UDP-glucuronosyltransferase 2B17 is an enzyme that in humans is encoded by the UGT2B17 gene.[5][6]

UGT2B17 belongs to the family of UDP-glucuronosyltransferases (UGTs; EC 2.4.1.17), enzymes that catalyze the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a variety of substrates, including steroid hormones.[supplied by OMIM][6] It also metabolizes 3-hydroxycotinine, which is minor nicotine metabolite[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197888Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035836Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Beaulieu M, Levesque E, Hum DW, Belanger A (Nov 1996). "Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids". J Biol Chem. 271 (37): 22855–62. doi:10.1074/jbc.271.37.22855. PMID 8798464.
  6. ^ a b "Entrez Gene: UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17".
  7. ^ Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (October 2010). "Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms". Cancer Research. 70 (19): 7543–52. doi:10.1158/0008-5472.CAN-09-4582. PMC 2998997. PMID 20876810.

Further reading

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