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Syntaphilin

From Wikipedia, the free encyclopedia
SNPH
Identifiers
AliasesSNPH, bA314N13.5, syntaphilin
External IDsOMIM: 604942; MGI: 2139270; HomoloGene: 8817; GeneCards: SNPH; OMA:SNPH - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014723
NM_001318234

NM_001291076
NM_001291077
NM_198214

RefSeq (protein)

NP_001305163
NP_055538

NP_001278005
NP_001278006
NP_937857

Location (UCSC)Chr 20: 1.27 – 1.31 MbChr 2: 151.59 – 151.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Syntaphilin is a protein that in humans is encoded by the SNPH gene. [5]

Function

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Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. Alternative splicing results in multiple transcript variants encoding different isoforms.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101298Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027457Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Syntaphilin". Retrieved 2016-11-01.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.