Salcaprozate sodium

Salcaprozate sodium
Identifiers
	IUPAC name sodium;8-[(2-hydroxybenzoyl)amino]octanoate;
CAS Number	203787-91-1;
PubChem CID	23669833;
ChemSpider	139678;
UNII	1YTW0422YU;
KEGG	D05787;
ChEMBL	ChEMBL2107027;
CompTox Dashboard (EPA)	DTXSID50174306 ;
Chemical and physical data
Formula	C15H20NNaO4
Molar mass	301.318 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C(=C1)C(=O)NCCCCCCCC(=O)[O-])O.[Na+];
	InChI InChI=InChI=1S/C15H21NO4.Na/c17-13-9-6-5-8-12(13)15(20)16-11-7-3-1-2-4-10-14(18)19;/h5-6,8-9,17H,1-4,7,10-11H2,(H,16,20)(H,18,19);/q;+1/p-1; Key:UOENJXXSKABLJL-UHFFFAOYSA-M;

Salcaprozate sodium (SNAC) is an intestinal permeation enhancer that is used in drug formulations particularly for macromolecules and poorly permeable compounds.^[1]^[2] SNAC has been used in formulations of drugs that have undergone clinical trials and has achieved generally recognized as safe (GRAS) status, with U.S. Food and Drug Administration approval for use in a medical food products.^[1]^[2]

An oral formulation of semaglutide that includes SNAC has been approved for use human use in the United States and Europe.^[3]

References

^ ^a ^b Twarog C, Fattah S, Heade J, Maher S, Fattal E, Brayden DJ (February 2019). "Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10)". Pharmaceutics. 11 (2): 78. doi:10.3390/pharmaceutics11020078. PMC 6410172. PMID 30781867.
^ ^a ^b Kommineni N, Sainaga Jyothi VG, Butreddy A, Raju S, Shapira T, Khan W, et al. (March 2023). "SNAC for Enhanced Oral Bioavailability: An Updated Review". Pharmaceutical Research. 40 (3): 633–650. doi:10.1007/s11095-022-03459-9. PMID 36539668.
^ Selvarajan R, Subramanian R (2023). "A Peptide in a Pill - Oral Semaglutide in the Management of Type 2 Diabetes". Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 16: 1709–1720. doi:10.2147/DMSO.S385196. PMC 10259523. PMID 37312901.

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