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Oxytocin/neurophysin i prepropeptide

From Wikipedia, the free encyclopedia
OXT
Identifiers
AliasesOXT, OT, OT-NPI, OXT-NPI, oxytocin/neurophysin I prepropeptide
External IDsOMIM: 167050; MGI: 97453; HomoloGene: 55494; GeneCards: OXT; OMA:OXT - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000915

NM_011025

RefSeq (protein)

NP_000906

NP_035155

Location (UCSC)Chr 20: 3.07 – 3.07 MbChr 2: 130.42 – 130.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Oxytocin/neurophysin I prepropeptide is a protein that in humans is encoded by the OXT gene. [5]

Function

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This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone that is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation, and complex sexual and maternal behavior, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101405Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027301Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Oxytocin/neurophysin I prepropeptide". Retrieved 2018-02-28.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.