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Orly Alter
אורלי אלטר
Orly Alter in the 2010s
Orly Alter in 2013
Born
Tel Aviv, Israel
Academic background
Alma mater
ThesisImpossibility of determining the quantum wavefunction of a single system and a fundamental limit to external force detection (1999)
Doctoral advisorYoshihisa Yamamoto
Academic work
Notable ideas eigengene,[1] multi-tensor comparative spectral decomposition[2]

Orly Alter (Hebrew: אורלי אלטר) is an Israeli-American physicist, geneticist, and mathematician, and a USTAR associate professor of bioengineering and human genetics at the Scientific Computing and Imaging Institute and the Huntsman Cancer Institute at the University of Utah.[3] She has published on quantum measurement, genomic signal processing, and tensor decompositions.

Education and career

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Alter began attending school at Tel Aviv University in Israel and graduated in October 1989 magna cum laude with her bachelors of science in physics.[3] After receiving her undergraduate degree, she began pursuing her Ph.D. in applied physics at the Stanford University in California, USA. She completed her Ph.D. with a thesis on “Impossibility of Determining the Quantum Wavefunction of a Single System and a Fundamental Limit to External Force Detection," under the mentorship of Yoshihisa Yamamoto in January 1999[4] and then moved onto a postdoctoral fellowship in genetics, remaining at Stanford.[5] Alter moved to the University of Utah in 2010, where she joined the Scientific Computing and Imaging Institute as a USTAR Associate Professor of Bioengineering.[6]

Following this, she became a member of Cancer Control and Population Sciences Program, and was co-founder and Chief Scientific Officer of Prism AI Therapeutics in 2024.[7]

Research

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Alter has one published book named Quantum Measurement of a Single System,[8][9] co-authored with Yamamoto, and another book in preparation, Genomic Signal Processing: Discovery of Principles of Nature from Matrix and Tensor Modeling of Large-Scale Molecular Biological Data.[10] Alter's work on finding patterns in DNA finds predictors indicative of a woman's risk for ovarian cancer,[11] and she uses mathematical models to improve the outcomes for women with ovarian cancer.[12][13][14]

Alter's team identified a DNA pattern as a predictor of survival in glioblastoma patients using new mathematical methods, which was reported in 2020.[15]

Awards and recognition

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In 2005 Alter was selected by the International Linear Algebra Society to give the Linear Algebra and its Applications Lecture.[16][17] Alter was an American Association of Physicists in Medicine Science Council Session Winner in 2014.[18]

Selected publications

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  • Alter, Orly; Brown, Patrick O.; Botstein, David (29 August 2000). "Singular value decomposition for genome-wide expression data processing and modeling". Proceedings of the National Academy of Sciences. 97 (18): 10101–10106. Bibcode:2000PNAS...9710101A. doi:10.1073/pnas.97.18.10101. ISSN 0027-8424. PMC 27718. PMID 10963673.
  • Alter, Orly; Brown, Patrick O.; Botstein, David (18 March 2003). "Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms". Proceedings of the National Academy of Sciences. 100 (6): 3351–3356. Bibcode:2003PNAS..100.3351A. doi:10.1073/pnas.0530258100. ISSN 0027-8424. PMC 152296. PMID 12631705.
  • Omberg, Larsson; Golub, Gene H.; Alter, Orly (20 November 2007). "A tensor higher-order singular value decomposition for integrative analysis of DNA microarray data from different studies". Proceedings of the National Academy of Sciences. 104 (47): 18371–18376. Bibcode:2007PNAS..10418371O. doi:10.1073/pnas.0709146104. ISSN 0027-8424. PMC 2147680. PMID 18003902.
  • Alter, Orly. Genomic Signal Processing: Discovery of Principles of Nature from Matrix and Tensor Modeling. Wiley. ISBN 978-1-119-07837-1.

References

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  1. ^ wiktionary:Citations:eigengene
  2. ^ Alter, Orly (31 January 2020). "Multi-Tensor Decompositions for Personalized Cancer Diagnostics, Prognostics, and Therapeutics" (video). www.youtube.com. Amazon Web Services.
  3. ^ a b "ORLY ALTER – Home – Faculty Profile – The University of Utah". faculty.utah.edu. Retrieved 13 March 2023.
  4. ^ Alter, Orly (1999). Impossibility of determining the quantum wavefunction of a single system and a fundamental limit to external force detection (Thesis).
  5. ^ "Alfred P. Sloan Foundation 1999 Annual Report" (PDF). sloan.org. Retrieved 5 February 2025.
  6. ^ "Orly Alter Joins the Scientific Computing and Imaging Institute as a USTAR Associate Professor of Bioengineering". www.sci.utah.edu. Retrieved 24 May 2024.
  7. ^ Alter, Orly. "Orly Alter – Curriculum Vitae". alterlab.org.
  8. ^ Alter, Orly. Quantum Measurement of a Single System. Wiley. ISBN 978-3527617128.
  9. ^ Donald, Matthew J. (February 2002). "Book Review - Quantum Measurement of a Single System by Orly Alter and Yoshihisa Yamamoto" (PDF). people.bss.phy.cam.ac.uk. Retrieved 8 March 2025.
  10. ^ Alter, Orly. Genomic Signal Processing: Discovery of Principles of Nature from Matrix and Tensor Modeling. Wiley. ISBN 978-1119078371.
  11. ^ "Increasing Accuracy of Diagnosis, Prognosis". USA Today; Farmingdale. Vol. 144, no. 2849. February 2016. p. 8 – via Proquest.
  12. ^ "U. researchers' mathematical models could provide better ovarian cancer treatment, outcomes". The Salt Lake Tribune; Salt Lake City, Utah. 15 April 2015 – via Proquest.
  13. ^ "Big Data, Hidden Knowledge". The Pathologist. Texere Publishing. 15 June 2015. Retrieved 12 March 2025.
  14. ^ "Calculating Cancer Cures". National Academy of Engineering (NAE) Innovation Podcast and Radio Series. NAE in Collaboration with WTOP Radio. 19 April 2019. Retrieved 12 March 2025.
  15. ^ "Genome-wide pattern found in tumors from brain cancer patients predicts life expectancy". EurekAlert!. University of Utah Health. 15 May 2020. Retrieved 8 March 2025.
  16. ^ "LAA-lecturers". International Linear Algebra Society. Retrieved 24 May 2024.
  17. ^ Alter, Orly (Fall 2005). Shader, Bryan L. (ed.). "Genomic Signal Processing: From Matrix Algebra to Genetic Networks" (PDF). The Bulletin of the International Linear Algebra Society. No. 35. pp. 2–14.
  18. ^ "AAPM Science Council Session Winner (SCSW) Recipients". aapm.org. Retrieved 8 March 2025.
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