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Jeff Firewalker Schmitt

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Jefferey D Schmitt (Jeff Firewalker Schmitt) is an American scientist, educator, folk healer, ceremonialist, and musician.[1][2][3][4] His career spans over forty years in the fields of medical research, molecular biophysics, education, native healing and music.[1][3][5] His work attempts to bridge the understanding between native mysticism and contemporary Western thought and science.[6]

Early life and work

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Jeff Schmitt was admitted to college early and published his first peer-reviewed article shortly thereafter.[7] He conducted research in cellular signal transduction for over a decade in the laboratory of Robert Wykle at Wake Forest University School of Medicine.[8][9] Beginning in 1994, Schmitt shifted his focus to the computational modeling of biological systems, an area that became a central part of his later scientific work.[10][11]

In addition to his academic pursuits, Schmitt was engaged in musical performance and writing [12]

Education and academic career

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Jeff Schmitt attended Wake Forest University where he was awarded a BS in Chemistry.[13] This was followed by a joint-university graduate study at the University of Bath and Oxford University where he obtained a doctorate in Molecular Biophysics. He held full professorships at the Wake Forest University's School of Medicine in Biochemistry, Physiology-Pharmacology and was a fellow of the NIH Translational Sciences Institute.[14] He also served as Research Director of Research at Wake Forest University's School of Medicine's Center for Integrative Medicine.[14]

Business and research career

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Schmitt has served as an educator, scientist, and inventor; he has also been an innovation and entrepreneurism coach.[1][2][15] He has served in several organizations, including Eagle Condor Council (founder), Wake Forest University School of Medicine, Bent Creek Institute of the University of North Carolina as their founding Scientific Director, Targacept, Inc. as a co-founder, Sanesco Health Inc. as their Chief Scientific Officer, and Illumivu/Cardiogram, Inc. as their Chief Data Scientist.[16][15]

Music: Saint Disruption and the Saint Disruption Podcast

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Schmitt is the co-founder of Saint Disruption, a musical collective done in collaboration with John Medeski, a jazz artist. The initiative is a blend of music, visual arts, and poetry.[17] The group has released several albums with Rose in the Oblivion as the debut album that is based on social and community issues. [1][2][4][5][12]

Publications

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  • Wykle RL, Miller CH, Lewis JC, Schmitt JD, Smith JA, Surles JR, Piantadosi C, O'Flaherty JT. (1981). Stereospecific activity of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and comparison of analogs in the degradation of platelets and neutrophils. Biochem Biophys Res Commun, 100:1651–1658.
  • O'Flaherty JT, Redman JF, Schmitt JD, Ellis JM, Surles JR, Marx MH, Piantadosi C, Wykle RL. (1987). 1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: A biologically potent, non-metabolizable analog of platelet-activating factor. Biochem Biophys Res Commun, 147(1):18–24.
  • Surles JR, Marx MH, Piantadosi C, Wykle RL, Schmitt JD. (1988). Synthesis and stability of glycerophosphochloridate. J Org Chem, 53:899–901.
  • Sozzani S, Agwu DE, McCall CE, O'Flaherty JT, Schmitt JD, Kent JD. (1992). Propranolol inhibits PKC. J Biol Chem, 267(28):20481–20488.
  • Schmitt JD, Sharples CG, Caldwell WS. (1999). Pi-cation interactions in nAChR binding. J Med Chem, 42(16):3066–3074.
  • Poole LB, Godzik A, Nayeem A, Schmitt JD. (2000). Functional dissection of AhpF. Biochemistry, 39:6602–6615.
  • Bayram E, Santago P, Harris R, et al. (2004). GAs + SOMs for QSAR/QSPR. J Comput Aided Mol Des, 18(7–9):483–493.
  • Vestal D, Thoma T, Harris R, Schmitt JD. (2007). Low-cost grid computing via community cooperation. Proc Annu Southeast Conf, 341–346.

References

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  1. ^ a b c d O'Brien, Andrew (2021-04-07). "Saint Disruption: Why Firewalker & John Medeski Delved Into Darkness In Search Of Ancient Medicine [Interview]". L4LM. Retrieved 2025-07-31.
  2. ^ a b c Himes, Geoffrey (2021-02-04). "Saint Disruption: John Medeski & Jeff Firewalker Schmitt Travel From the Jungle to the Street". American Songwriter. Retrieved 2025-07-31.
  3. ^ a b May, Jake (2021-02-04). "John Medeski and Scientist Jeff Firewalker Schmitt Team Up for New Project Saint Disruption, Share First Single". Jambands. Retrieved 2025-07-31.
  4. ^ a b Broerman, Michael (2021-03-04). "John Medeski's Saint Disruption Confronts Consumerism On "Instant Gratification" [Watch]". L4LM. Retrieved 2025-07-31.
  5. ^ a b "After Meeting In The Amazon, John Medeski, And Jeff Firewalker Schmitt Join Forces As Saint Disruption". Top40-Charts.com. Retrieved 2025-07-31.
  6. ^ "Healing from Within - Internet Radio Show". sherylglick.com. Retrieved 2025-07-31.
  7. ^ Wykle, Robert L.; Miller, Craig H.; Lewis, Jon C.; Schmitt, Jeffrey D.; Smith, Jennie A.; Surles, Jefferson R.; Piantadosi, Claude; O'Flaherty, Joseph T. (June 1981). "Stereospecific activity of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and comparison of analogs in the degranulation of platelets and neutrophils". Biochemical and Biophysical Research Communications. 100 (4): 1651–1658. Bibcode:1981BBRC..100.1651W. doi:10.1016/0006-291x(81)90708-7. ISSN 0006-291X. PMID 7295320.
  8. ^ O'Flaherty, Joseph T.; Redman, J.F.; Schmitt, Jeffrey D.; Ellis, J. Marshall; Surles, Jefferson R.; Marx, Michael H.; Piantadosi, Claude; Wykle, Robert L. (August 1987). "1-0-alkyl-2-N-methylcarbamyl-glycerophosphocholine: A biologically potent, non-metabolizable analog of platelet-activating factor". Biochemical and Biophysical Research Communications. 147 (1): 18–24. Bibcode:1987BBRC..147...18O. doi:10.1016/s0006-291x(87)80081-5. ISSN 0006-291X. PMID 2820395.
  9. ^ O'Flaherty, Joseph T.; Schmitt, Jeffery D.; Wykle, Robert L. (March 1985). "Interactions of arachidonate metabolism and protein kinase C in mediating neutrophil function". Biochemical and Biophysical Research Communications. 127 (3): 916–923. Bibcode:1985BBRC..127..916O. doi:10.1016/s0006-291x(85)80031-0. ISSN 0006-291X. PMID 2985065.
  10. ^ Schmitt, Jeffrey D.; Sansom, M. S. P.; Kerr, I. D.; Lunt, G. G.; Eisenthal, R. (1997-02-01). "Ferrocenoyl Derivatives of Alamethicin: Redox-Sensitive Ion Channels". Biochemistry. 36 (5): 1115–1122. doi:10.1021/bi962168w. ISSN 0006-2960. PMID 9033402.
  11. ^ Clement, Jason A.; Bleich, Rachel M.; Campbell, Hailey E.; Naylor, Kristin; Flood, Matthew J.; Kelly, Ryan M.; Wu, Shi-Biao; Kennelly, Edward J.; Schmitt, Jeffrey D. (2016-09-16). "Cytotoxic oplopane sesquiterpenoids from Arnoglossum atriplicifolium". Natural Product Research. 30 (18): 2028–2033. doi:10.1080/14786419.2015.1107063. ISSN 1478-6419. PMID 26540019.
  12. ^ a b LMNR (2021-03-03). "Saint Disruption | Live Music News". Retrieved 2025-07-31.
  13. ^ "Jeff Schmitt: Transforming Disruptive Ideas into Profitable Innovation and Resilient Change Through Enthusiastic Collaboration". leadafi.com. Retrieved 2025-08-01.
  14. ^ a b "The Loretta Brown Show – 11 – 14 -17 – Jeffrey Schmitt, Ph.D." Alternative Talk 1150 KKNW. 2019-11-14. Retrieved 2025-07-31.
  15. ^ a b Liu, CJ (2020-10-28). "Freedom From Tobacco". Fireitupwithcj. Retrieved 2025-07-31.
  16. ^ Westfall, Susan (2019-08-07). "All of My Relations (AoMR) with Jeffrey Schmitt PhD – New Human Living". Retrieved 2025-07-31.
  17. ^ "Across The Margin : The Podcast — Jeff Firewalker Schmitt of Saint Disruption". Across the Margin. 2021-03-11. Retrieved 2025-08-01.
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