Hiroyuki Sasaki

Hiroyuki Sasaki (佐々木 裕之, Sasaki Hiroyuki; born 1956) is a Japanese geneticist known for contributing to clarify epigenetic regulations during gametogenesis and embryogenesis through investigation of genomic imprinting as a model. He participates in the International Human Epigenome Consortium [IHEC].

Biography

Sasaki was born in Fukuoka, Japan in 1956, and received his MD and PhD in 1982 and 1987, respectively, from Kyushu University. He was appointed as a professor of the National Institute of Genetics in 1998. He has been a professor at the Medical Institute of Bioregulation, Kyushu University since 2010, where he has been serving as a dean since 2012. He has been a vice president of Kyushu University since 2015, and a dean of the Institute for Advanced Study, Kyushu University since 2018. In 2025, Sasaki found the genetic mutation that causes Orange cats.

Awards

• 2009: The Japan Society of Human Genetics award
• 2012: Kihara Award of the Genetics Society of Japan
• 2015: Purple Ribbon Medal

References

• Sasaki H; et al. (1985). "Presymptomatic diagnosis of heterozygosity for familial amyloidotic polyneuropathy by recombinant DNA techniques". Lancet. 325 (8420): 100. doi:10.1016/S0140-6736(85)91985-3. PMID 2856994.
• Ferguson-Smith AC; et al. (1993). "Parental-origin-specific epigenetic modification of the mouse H19 gene". Nature. 362 (6422): 751–755. doi:10.1038/362751a0. PMID 8469285.
• Kaneda M; et al. (2004). "Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting". Nature. 429 (6994): 900–903. doi:10.1038/nature02633. PMID 15215868.
• Watanabe T; et al. (2008). "Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes". Nature. 453 (7194): 539–543. doi:10.1038/nature06908. PMID 18404146.
• Sasaki H and Matsui Y. (2008). "Epigenetic events in mammalian germ-cell development: reprogramming and beyond". Nat. Rev. Genet. 9 (2): 129–140. doi:10.1038/nrg2295. PMID 18197165.
• Watanabe T; et al. (2011). "Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus". Science. 332 (6031): 848–852. doi:10.1126/science.1203919. PMC 3368507. PMID 21566194.
• Stunnenberg HG; et al. (2016). "The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery" (PDF). Cell. 167 (5): 1145–1149. doi:10.1016/j.cell.2016.11.007. PMID 27863232.
• Yamashiro C; et al. (2018). "Generation of human oogonia from induced pluripotent stem cells in vitro". Science. 362 (6412): 356–360. doi:10.1126/science.aat1674. hdl:2433/242826. PMID 30237246.

External links

• Videos of keynote speakers in Vienna - Hiroyuki Sasaki
• Hiroyuki Sasaki (Kyushu University)
• IHEC Japan