Draft:Francis J. Castellino
 | Review waiting, please be patient.
This may take 2 months or more, since drafts are reviewed in no specific order. There are 2,442 pending submissions waiting for review.
Where to get help
How to improve a draft
You can also browse Wikipedia:Featured articles and Wikipedia:Good articles to find examples of Wikipedia's best writing on topics similar to your proposed article. Improving your odds of a speedy review To improve your odds of a faster review, tag your draft with relevant WikiProject tags using the button below. This will let reviewers know a new draft has been submitted in their area of interest. For instance, if you wrote about a female astronomer, you would want to add the Biography, Astronomy, and Women scientists tags. Editor resources
Reviewer tools
|
| Submission declined on 6 March 2025 by Pythoncoder (talk). The content of this submission includes material that does not meet Wikipedia's minimum standard for inline citations. Please cite your sources using footnotes. For instructions on how to do this, please see Referencing for beginners. Thank you.
Where to get help
How to improve a draft
You can also browse Wikipedia:Featured articles and Wikipedia:Good articles to find examples of Wikipedia's best writing on topics similar to your proposed article. Improving your odds of a speedy review To improve your odds of a faster review, tag your draft with relevant WikiProject tags using the button below. This will let reviewers know a new draft has been submitted in their area of interest. For instance, if you wrote about a female astronomer, you would want to add the Biography, Astronomy, and Women scientists tags. Editor resources
This draft has been resubmitted and is currently awaiting re-review. |  |
Francis J. Castellino (also known as Frank Castellino) is an American biochemist known for his contributions to the study of hemostasis, infection, and inflammation, particularly in relation to sepsis. He has extensively researched the Streptococcus pyogenes strain AP53, focusing on bacterial and mouse transgenesis and genetics. Castellino has been a professor at the University of Notre Dame since 1970 and has served in several administrative roles, including as the Dean of the Notre Dame College of Science from 1979 to 2002.[1]
Early Life and Education
[edit]Castellino was the first in his family to obtain a college degree. He received his B.S. in 1964 from the University of Scranton and his Ph.D. in 1968 from the University of Iowa, where he studied biochemistry. He then completed an NIH Postdoctoral Fellowship at Duke University.[2]
Career
[edit]Academic Positions
[edit]Castellino began his academic career at the University of Notre Dame in 1970 as an Assistant Professor in the Department of Chemistry and Biochemistry. He became a full Professor in 1977 and was appointed Kleiderer-Pezold Professor of Biochemistry in 1982.
From 1979 to 2002, he served as the Dean of the Notre Dame College of Science, overseeing advancements in research and education in the sciences. In 1996, he founded the W. M. Keck Center for Transgene Research at Notre Dame. The center was renamed in 1998 after receiving funding from the W. M. Keck Foundation to expand its infrastructure.[3]
Research Contributions
[edit]Over a career spanning more than 50 years, Castellino has conducted pioneering research in the field of fibrinolysis, hemostasis, and inflammation. He has:
Investigated the biochemical properties of plasminogen and its role in fibrinolysis, especially Kringle 2 domain.[4][5]
Developed gene knockout and mutant mice models in hemostasis studies.[6]
Explored the interaction between Group A Streptococcus and host proteins to understand bacterial pathogenesis.[7][8]
Studied Vitamin K-dependent gamma-carboxylated peptides from venomous cone snails as models for protein coagulation domains.[9]
His work has been widely cited in scientific literature, including contributions to studies on Angiostatin.[10]
Honors and Awards
[edit]Castellino has received numerous awards throughout his career, including:
NIH Research Career Development Award (1974–1979)
Camille and Henry Dreyfus Teacher-Scholar Award (1974–1979)
MERIT Award (HL-13423), NHLBI, NIH (1990)
Educator of the Year Award, Michiana Executive Journal (1995)
Wyeth-ISFP Prize for Research in Fibrinolysis (2008)
Distinguished Alumnus Award for Achievement, University of Iowa Carver College of Medicine (2014).[11]
He has also been elected a Fellow of multiple scientific societies, including the American Association for the Advancement of Science (AAAS) and the American Heart Association.
Professional Memberships and Editorial Roles
[edit]Castellino has been an active member of numerous scientific organizations and editorial boards:
Editor-in-Chief of Current Drug Targets (1998-2024)
Editorial Board Member of the Journal of Biological Chemistry and Biotechnology and Applied Biochemistry
NIH Hematology Study Section Chair (1992–1994)
References
[edit]- ^ "Francis J. Castellino Profile". University of Notre Dame. Retrieved 2025-03-06.
- ^ "Indiana University Faculty Profile". Indiana University. Retrieved 2025-03-06.
- ^ "W. M. Keck Foundation Annual Reports". W. M. Keck Foundation. Retrieved 2025-03-06.
- ^ Castellino FJ, Beals JM (1987). "The genetic relationships between the kringle domains of human plasminogen, prothrombin, tissue plasminogen activator, urokinase, and coagulation factor XII". J. Mol. Evol. 26 (4): 358–369. Bibcode:1987JMolE..26..358C. doi:10.1007/BF02101155. PMID 3131537. S2CID 22249781.
- ^ Rios-Steiner, J.L.; Schenone, M.M.; Mochalkin, I.; Francis J., A.; Castellino (2001). "Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an internal peptide from a Group A Streptococcal surface protein". Journal of Molecular Biology. 308 (4): 705–719. doi:10.1006/jmbi.2001.4646. PMID 11350170.
{{cite journal}}: Unknown parameter|DUPLICATE_last4=ignored (help) - ^ Iwaki, T.; Malinverno, C.; Smith, D.; Francis J., Z.; Castellino (2021). "Plasminogen Deficiency Significantly Reduces Vascular Wall Disease in a Murine Model of Type IIa Hypercholesterolemia". Biomedicines. 9 (12): 1832. doi:10.3390/biomedicines9121832. PMC 8698429. PMID 34944648.
{{cite journal}}: Unknown parameter|DUPLICATE_last4=ignored (help) - ^ "Speaker Profile – Infectious Congress". Infectious Congress. Retrieved 2025-03-06.
- ^ Yuan, Y.; Ayinuola, Y.A.; Singh, D.; Mayfield, J.A.; Quek, A.; Whisstock, J.C.; Law, R.H.P.; Lee, L.; Francis J., Castellino (2019). "Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes". Journal of Structural Biology. 208 (1): 18–29. doi:10.1016/j.jsb.2019.07.005. PMC 6983471. PMID 31301349.
- ^ Holmes, A.; Zhou, N.; Donahue, D.L.; Francis J., R.; Castellino (2018). "A deficiency of the GluN2C subunit of the N-methyl-D-aspartate receptor is neuroprotective in a mouse model of ischemic stroke". Biochem Biophys Res Commun. 495 (1): 136–144. doi:10.1016/j.bbrc.2017.10.171. PMID 29101031.
{{cite journal}}: Unknown parameter|DUPLICATE_last4=ignored (help) - ^ Abad, Marta C.; Arni, R.K.; Grella, Davida K.; Castellino, Francis J.; Tulinsky, Alexander; Geiger, James H. (2002-05-10). "The X-ray Crystallographic Structure of the Angiogenesis Inhibitor Angiostatin". Journal of Molecular Biology. 318 (4): 1009–1017. doi:10.1016/S0022-2836(02)00211-5. PMID 12054798.
- ^ "ISTH Esteemed Career Recognition". International Society on Thrombosis and Haemostasis (ISTH). Retrieved 2025-03-06.
External Links
[edit]W. M. Keck Center for Transgene Research
Speaker Event at University of Maryland BioPark
University of Notre Dame Faculty Profile
Indiana University Faculty Profile |publisher=Indiana University
Speaker Profile – Infectious Congress