11C ME@HAPTHI

11C ME@HAPTHI
Identifiers
	IUPAC name (S)-1-(3-Hydroxy-4-([11C]methylamino)butyl)-3-phenyl-1,3-dihydrobenzo[c][1,2,5]thiadiazole,2,2-dioxide;
CAS Number	1033218-58-4 ;
PubChem CID	165360096;
ChemSpider	129562584;
CompTox Dashboard (EPA)	DTXSID601335993 ;
Chemical and physical data
Formula	C17H21N3O3S
Molar mass	347.43 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [11CH3]NC[C@@H](O)CCN1C2=C(C=CC=C2)N(C2=CC=CC=C2)S1(=O)=O;
	InChI InChI=1S/C17H21N3O3S/c1-18-13-15(21)11-12-19-16-9-5-6-10-17(16)20(24(19,22)23)14-7-3-2-4-8-14/h2-10,15,18,21H,11-13H2,1H3/t15-/m0/s1/i1-1; Key:OIFBYCGNUDQJBL-FZTOSIJBSA-N;

[11C]ME@HAPTHI is a chemical compound used as a radiotracer to image the norepinephrine transporter (NET) protein using positron emission tomography (PET).^[1] The NET protein is of research interest for its role in various neuropsychiatric disorders, such as ADHD and depression.^[1]

References

^ ^a ^b Rami-Mark C, Berroterán-Infante N, Philippe C, Foltin S, Vraka C, Hoepping A, Lanzenberger R, Hacker M, Mitterhauser M, Wadsak W (Dec 2015). "Radiosynthesis and first preclinical evaluation of the novel norepinephrine transporter pet-ligand [(11)C]ME@HAPTHI". EJNMMI Research. 5 (34) 34: 113. doi:10.1186/s13550-015-0113-3. PMC 4467816. PMID 26061602.

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